Folate (categories 2)
Folate range (<40 vs >=40)
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
229.3346032
|
1
|
<0.0001
|
***
|
|
Folate_gp2
|
2.4595598
|
1
|
0.1
|
ns
|
|
Study
|
0.5016894
|
1
|
0.5
|
ns
|
|
GA_samp
|
173.6025363
|
1
|
<0.0001
|
***
|
|
Folate_gp2:Study
|
1.6178809
|
1
|
0.2
|
ns
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
41.6985648
|
1
|
<0.0001
|
***
|
|
Folate_gp2
|
0.3767370
|
1
|
0.5
|
ns
|
|
Study
|
13.4402945
|
1
|
0.0002
|
***
|
|
GA_samp
|
2493.7981827
|
1
|
<0.0001
|
***
|
|
Folate_gp2:Study
|
0.1843189
|
1
|
0.7
|
ns
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
416.3034217
|
1
|
<0.0001
|
***
|
|
Folate_gp2
|
0.5199859
|
1
|
0.5
|
ns
|
|
Study
|
0.0000572
|
1
|
1.0
|
ns
|
|
GA_samp
|
1063.6192459
|
1
|
<0.0001
|
***
|
|
Folate_gp2:Study
|
0.2606543
|
1
|
0.6
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp2
|
1
|
Inf
|
0.141
|
0.141
|
0.7
|
ns
|
|
3
|
Study
|
1
|
Inf
|
10.517
|
10.517
|
0.001
|
**
|
|
4
|
GA_samp
|
1
|
Inf
|
0.967
|
0.967
|
0.3
|
ns
|
|
2
|
Folate_gp2:Study
|
1
|
Inf
|
3.702
|
3.702
|
0.05
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp2
|
1
|
Inf
|
0.025
|
0.025
|
0.9
|
ns
|
|
3
|
Study
|
1
|
Inf
|
24.928
|
24.928
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.504
|
0.504
|
0.5
|
ns
|
|
2
|
Folate_gp2:Study
|
1
|
Inf
|
3.456
|
3.456
|
0.06
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp2
|
1
|
Inf
|
1.254
|
1.254
|
0.3
|
ns
|
|
3
|
Study
|
1
|
Inf
|
136.147
|
136.147
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.326
|
0.326
|
0.6
|
ns
|
|
2
|
Folate_gp2:Study
|
1
|
Inf
|
0.255
|
0.255
|
0.6
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
15.45 (10.83, 22.04)
|
<0.0001
|
|
Folate_gp2≥40
|
0.97 (0.92, 1.03)
|
0.36
|
|
StudySTOP
|
0.99 (0.89, 1.10)
|
0.86
|
|
GA_samp
|
1.15 (1.13, 1.18)
|
<0.0001
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.84 (1.53, 2.21)
|
<0.0001
|
|
Folate_gp2≥40
|
1.01 (0.98, 1.04)
|
0.66
|
|
StudySTOP
|
1.12 (1.06, 1.18)
|
0.0001
|
|
GA_samp
|
1.34 (1.32, 1.36)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.08 (0.06, 0.10)
|
<0.0001
|
|
Folate_gp2≥40
|
0.96 (0.92, 1.00)
|
0.08
|
|
StudySTOP
|
0.99 (0.92, 1.07)
|
0.81
|
|
GA_samp
|
1.30 (1.28, 1.32)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
12.48 (7.90, 19.71)
|
<0.0001
|
|
Folate_gp2≥40
|
0.97 (0.89, 1.05)
|
0.46
|
|
StudySTOP
|
0.80 (0.69, 0.92)
|
0.002
|
|
GA_samp
|
1.01 (0.99, 1.04)
|
0.32
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
3.16 (1.95, 5.12)
|
<0.0001
|
|
Folate_gp2≥40
|
0.98 (0.90, 1.07)
|
0.61
|
|
StudySTOP
|
0.69 (0.59, 0.80)
|
<0.0001
|
|
GA_samp
|
1.01 (0.98, 1.04)
|
0.47
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
5.60 (5.14, 6.11)
|
<0.0001
|
|
Folate_gp2≥40
|
1.01 (0.99, 1.03)
|
0.22
|
|
StudySTOP
|
0.86 (0.84, 0.88)
|
<0.0001
|
|
GA_samp
|
1.00 (0.99, 1.00)
|
0.55
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
97.59156
|
7.250616
|
83.77818
|
84.187
|
113.1304
|
|
STOP
|
96.70558
|
6.867894
|
70.04977
|
83.934
|
111.4205
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
88.46211
|
2.325528
|
144.1406
|
83.98294
|
93.18017
|
|
STOP
|
98.82432
|
2.380021
|
101.7462
|
94.21441
|
103.65980
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
2.328197
|
0.0639117
|
393.6499
|
2.205877
|
2.45730
|
|
STOP
|
2.307065
|
0.0527727
|
220.1818
|
2.205370
|
2.41345
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
14.94055
|
0.7244048
|
Inf
|
13.58612
|
16.43001
|
|
STOP
|
11.89215
|
0.4304671
|
Inf
|
11.07768
|
12.76650
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
3.632878
|
0.1870699
|
Inf
|
3.284123
|
4.018669
|
|
STOP
|
2.489792
|
0.0951203
|
Inf
|
2.310168
|
2.683381
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
5.500541
|
0.0501650
|
Inf
|
5.403093
|
5.599747
|
|
STOP
|
4.730796
|
0.0344955
|
Inf
|
4.663667
|
4.798892
|
Comparisons (Overall)
|
Hormone
|
Contrast
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
≥40 / <40
|
0.97 (0.92, 1.03)
|
0.4
|
|
hPL (μg/ml)
|
≥40 / <40
|
1.01 (0.98, 1.04)
|
0.7
|
|
GH2 (ng/ml)
|
≥40 / <40
|
0.96 (0.92, 1.00)
|
0.08
|
|
Insulin (uU/ml)
|
≥40 / <40
|
0.97 (0.89, 1.05)
|
0.5
|
|
HOMA-IR
|
≥40 / <40
|
0.98 (0.90, 1.07)
|
0.6
|
|
Glucose (mmol/L)
|
≥40 / <40
|
1.01 (0.99, 1.03)
|
0.2
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)
